The Ultimate Buyer's Guide for Purchasing medicinal intermediates

Active pharmaceutical ingredients (APIs) are the essential components in pharmaceutical drugs that provide the necessary effect to treat medical conditions. These APIs are created by processing chemical compounds. In the case of biologic drugs, the active ingredient is referred to as a bulk process intermediate (BPI).

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Despite high manufacturing costs, strict regulatory policies, and price control measures in various countries, there are promising opportunities in the API market. This is largely attributed to the rising prevalence of chronic diseases such as diabetes, asthma, and cancer.

The information contained in the downloadable document is designed for pharmaceutical executives, research and development (R&D) leaders, quality control and quality assurance professionals, as well as API manufacturers, distributors, suppliers, sales managers, process engineers, technicians, research associates, production chemists, and others involved in the API and medicinal intermediate industry.

This document includes comprehensive information on API manufacturers, aiding in purchasing decisions with details about product ranges and contact information.

Related buyer's guides, which encompass a wide array of pharmaceutical technologies, equipment, and manufacturers, are also available.

Types of Active Pharmaceutical Ingredients

APIs can be broadly classified into two categories: synthetic and natural. Synthetic APIs are further divided into innovative and generic synthetic APIs based on the synthesis method utilized.

Synthetic chemical APIs, commonly known as small molecules, represent a significant share of the pharmaceutical market, with numerous small molecule drugs available commercially.

Natural APIs are typically used in the production of biologics, which are increasingly identified as top-selling drugs. However, despite the growing demand, the number of biologics remains considerably lower than that of small molecule drugs.

APIs can also be categorized based on solubility into insoluble and soluble drugs.

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Top Active Pharmaceutical Ingredients and Intermediates Suppliers

Pharmaceutical Technology has identified leading suppliers of active pharmaceutical ingredients and intermediates based on extensive insights, intel, and decades-long experience in the industry. This list includes companies capable of developing and supplying high-quality pharmaceutical materials, including but not limited to:

• Fine chemicals and intermediates, such as high-docosahexaenoic acid oil for API production
• APIs for central nervous system therapies
• Natural cannabinoid (CBD) ingredients, CBD isolates, and cannabis distillates
• Excipients
• Insulin for cell culture media
• Ammonium compounds
• Mineral salts

The list also covers suppliers of mixing and drying technologies, polymer coatings for drug delivery, extraction technologies for high-purity APIs, and dispersion and wet milling technology. Additionally, providers of automatic capsule filling machines, dry powder and liquid-based material handling systems, analytical services for biological assays, pharmaceutical tablet manufacturing machines, and custom synthesis services are detailed within the document.

FAQs

What are Active Pharmaceutical Ingredients (APIs)?

Active pharmaceutical ingredients (APIs) are the biologically active elements within drugs that produce the intended therapeutic effect. APIs can be either synthetic, created through chemical processes, or derived from natural sources such as plants or animals. The API is combined with other substances known as excipients to formulate the final pharmaceutical product.

What are the main types of APIs?

APIs are primarily categorized into synthetic and natural types. Synthetic APIs, which include small molecule drugs, dominate the pharmaceutical market. Conversely, natural APIs are utilized in biologics, such as vaccines and cell therapies, though they are less abundant.

How are APIs classified based on solubility?

APIs are divided into soluble and insoluble categories. Soluble APIs dissolve in bodily fluids, enhancing absorption, whereas insoluble APIs necessitate specialized formulations for effective delivery and absorption in the body.

Who uses API buyer's guides?

The buyer's guide is utilized by pharmaceutical executives, R&D teams, quality control specialists, and API manufacturers. It provides critical insights into API suppliers, product ranges, and contact details, enabling users to make informed purchasing decisions.

What opportunities exist in the API market?

In spite of challenges like high manufacturing costs and regulatory barriers, the API market continues to thrive. This growth is primarily driven by the rising incidence of chronic conditions such as diabetes, asthma, and cancer, along with an increasing demand for biologics and advanced therapeutics.

For full details (including contact details) on the leading companies within this space, download the free buyer's guide below:

Buyer's Guides | Issue 143 | June