2-Hydroxy-6-(Trifluoromethyl)pyridine vs. Standard Pyridine: Key Differences Explained

With competitive price and timely delivery, huimeng sincerely hope to be your supplier and partner.

2-Hydroxy-6-(Trifluoromethyl)pyridine vs. Standard Pyridine: Key Differences Explained

Pyridine, a heterocyclic aromatic organic compound with the formula C5H5N, is widely used in various industrial applications, including the manufacture of agrochemicals, pharmaceuticals, and chemicals. A derivative, 2-Hydroxy-6-(Trifluoromethyl)pyridine, has gained attention due to its unique properties. Below, we explore the key differences between this derivative and standard pyridine.

1. Chemical Structure:
   • Standard pyridine features a simple six-membered ring containing five carbon atoms and one nitrogen atom.
   • 2-Hydroxy-6-(Trifluoromethyl)pyridine consists of a hydroxyl group (-OH) and a trifluoromethyl group (-CF3) attached to the pyridine ring, enhancing its chemical reactivity.
2. Physicochemical Properties:
   • Standard pyridine is a colorless liquid with a boiling point of 115.2°C and a characteristic odor.
   • 2-Hydroxy-6-(Trifluoromethyl)pyridine has a higher boiling point due to additional bonds resulting from the electronegative fluorine atoms and the presence of the hydroxyl group.
3. Reactivity:
   • Standard pyridine is relatively stable but can undergo electrophilic substitution reactions.
   • In contrast, 2-Hydroxy-6-(Trifluoromethyl)pyridine is more reactive, particularly in nucleophilic substitution, due to the presence of the hydroxyl group that can act as a leaving group.
4. Applications:
   • Standard pyridine serves as a solvent in various chemical reactions and is a precursor for numerous industrial chemicals.
   • 2-Hydroxy-6-(Trifluoromethyl)pyridine is particularly useful in pharmaceuticals and agrochemicals, where enhanced biological activity is desired due to its unique functional groups.
5. Biodistribution:
   • Standard pyridine has moderate bioavailability and can be toxic in high concentrations.
   • The presence of the trifluoromethyl group in 2-Hydroxy-6-(Trifluoromethyl)pyridine can alter its biodistribution, potentially increasing lipophilicity and affecting how the compound interacts with biological systems.
6. Toxicity:
   • Standard pyridine is classified as a hazardous substance and poses risks including respiratory irritation and potential long-term health effects.
   • In comparison, 2-Hydroxy-6-(Trifluoromethyl)pyridine's toxicity profile can vary, and its specific effects still need comprehensive investigation, especially considering fluorinated compounds often exhibit unique toxicity patterns.

In summary, while standard pyridine is widely utilized in various applications, 2-Hydroxy-6-(Trifluoromethyl)pyridine offers distinct advantages and reactivity, making it an intriguing compound for research and industry. Understanding these differences is crucial for scientists and engineers in selecting the right compound for their specific needs.

View Details

Want more information on 2-Hydroxy-6-( Trifluoromethyl )pyridine solution? Feel free to contact us.